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<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
\n\t\t\t\t\n\t\t\t\t\t\u306f\u3058\u3081\u306b<\/strong><\/p>
\u3000\u30d7\u30ed\u30d0\u30a4\u30aa\u30c6\u30a3\u30af\u30b9\uff08Probiotics; \u4ee5\u4e0bPb\u3068\u7565\u3059\uff09\u306e\u6982\u5ff5\u306f\uff12\uff10\u4e16\u7d00\u521d\u982d\u3001\u514d\u75ab\u98df\u7d30\u80de\u306e\u7814\u7a76\u3067\u30ce\u30fc\u30d9\u30eb\u8cde\u3092\u5f97\u305f\u30a4\u30ea\u30a2\u30fb\u30e1\u30c1\u30cb\u30b3\u30d5\uff081845~1910\uff09\u306b\u3088\u308a\u63d0\u5531\u3055\u308c\u305f\u3002\u8001\u5316\u3092\u7814\u7a76\u3057\u3066\u3044\u305f\u30e1\u30c1\u30cb\u30b3\u30d5\u306f\u3001\u8178\u5185\u306b\u5b9a\u4f4f\u3059\u308b\u8150\u6557\u83cc\u304c\u51fa\u3059\u8150\u6557\u7269\u8cea\u304c\u8001\u5316\u3092\u5f15\u304d\u8d77\u3053\u3059\u539f\u56e0\u3067\u3042\u308b\u3068\u4e88\u60f3\u3057\u3066\u3044\u305f\u3002\u5f53\u6642\u3001\u30d6\u30eb\u30ac\u30ea\u30a2\u306f\u9577\u5bff\u56fd\u3068\u3057\u3066\u77e5\u3089\u308c\u3066\u3044\u305f\u304c\u3001\u305d\u306e\u7406\u7531\u306f\u3001\u30d6\u30eb\u30ac\u30ea\u30a2\u4eba\u304c\u591a\u91cf\u306b\u6d88\u8cbb\u3059\u308b\u30e8\u30fc\u30b0\u30eb\u30c8\u306b\u306f\u4e73\u9178\u687f\u83cc\u304c\u591a\u304f\u542b\u307e\u308c\u3001\u3053\u308c\u3089\u304c\u8178\u5185\u8150\u6557\u83cc\u306e\u6d3b\u52d5\u3092\u6291\u3048\u308b\u305f\u3081\u3067\u3042\u308b\u3068\u3001\u5f7c\u306f\u8003\u3048\u305f\u3002\u3053\u306e\u3088\u3046\u306b\u6709\u76ca\u83cc\u3092\u7528\u3044\u3066\u3001\u8178\u5185\u5e38\u5728\u83cc\u3068\u3057\u3066\u68f2\u606f\u3059\u308b\u6709\u5bb3\u83cc\u3092\u6291\u5236\u3059\u308b\u3053\u3068\u3067\u3001\u5065\u5eb7\u7dad\u6301\u3042\u308b\u3044\u306f\u75be\u75c5\u4e88\u9632\u3092\u884c\u3046\u3068\u3044\u3046\u3001\u73fe\u5728\u306ePb\u306e\u8003\u3048\u65b9\u306f\u30e1\u30c1\u30cb\u30b3\u30d5\u306b\u3088\u3063\u3066\u5275\u59cb\u3055\u308c\u305f\u3068\u8a00\u3048\u308b\u3002\u672c\u7a3f\u3067\u306fPb\u306e\u57fa\u790e\u3001\u305d\u3057\u3066Helicobacter pylori<\/em>\uff08\u4ee5\u4e0b\u3001\u30d4\u30ed\u30ea\u83cc\u3068\u7565\u3059\uff09\u611f\u67d3\u75c7\u306e\u6cbb\u7642\u3001\u4e88\u9632\u306b\u304a\u3051\u308bPb\u5fdc\u7528\u306e\u73fe\u72b6\u306b\u3064\u3044\u3066\u8ff0\u3079\u308b\u3002<\/p>
\u00a0<\/strong><\/p>
Pb\u3068\u306f<\/strong><\/p>
\u3000Pb\u3068\u306f\u53e3\u8154\u304b\u3089\u809b\u9580\u306b\u81f3\u308b\u5e83\u7fa9\u306e\u6d88\u5316\u7ba1\u306b\u5b9a\u4f4f\u3059\u308b\u5e38\u5728\u7d30\u83cc\u7fa4\u306b\u50cd\u304d\u304b\u3051\u3066\u3001\u3042\u308b\u3044\u306f\u5358\u72ec\u3067\u3001\u751f\u4f53\u306b\u6709\u76ca\u306a\u52b9\u679c\u3092\u3082\u305f\u3089\u3059\u751f\u304d\u305f\u83cc\u3092\u6307\u3059\u7528\u8a9e\u3067\u3042\u308b\u3002\u73fe\u5728\u3001\u4e3b\u306b\u4e73\u9178\u687f\u83cc\u304a\u3088\u3073\u30d3\u30d5\u30a3\u30ba\u30b9\u83cc\u304cPb\u3068\u3057\u3066\u7528\u3044\u3089\u308c\u3066\u3044\u308b\u3002\u76ae\u819a\u3001\u5916\u90e8\u5c3f\u9053\u3001\u81a3\u306b\u3082\u5e38\u5728\u7d30\u83cc\u304c\u5b9a\u7740\u3057\u3066\u304a\u308a\u3001Pb\u5fdc\u7528\u306e\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002\u307e\u305f\u985e\u4f3c\u8a9e\u306e\u30d7\u30ec\u30d0\u30a4\u30aa\u30c6\u30a3\u30af\u30b9\uff08Prebiotics\uff09\u306f\u8178\u5185\u306e\u6709\u76ca\u83cc\u3092\u5897\u3084\u3059\u7269\u8cea\u306e\u3053\u3068\u3092\u6307\u3057\u3001\u30d3\u30d5\u30a3\u30ba\u30b9\u83cc\u3092\u9078\u629e\u7684\u306b\u5897\u6b96\u3055\u305b\u308b\u30aa\u30ea\u30b4\u7cd6\u304c\u3001\u73fe\u5728\u3001\u4ee3\u8868\u7684\u306a\u30d7\u30ec\u30d0\u30a4\u30c6\u30a3\u30af\u30b9\u3068\u3057\u3066\u4f7f\u7528\u3055\u308c\u3066\u3044\u308b\u3002<\/p>
\u3000Pb\u306f\u3001\u4ee5\u4e0b\u306b\u5217\u6319\u3059\u308b\u5e38\u5728\u7d30\u83cc\u306e\u751f\u4f53\u306b\u53ca\u307c\u3059\u6709\u76ca\u306a\u52b9\u679c\u3092\u80a9\u4ee3\u308f\u308a\u3059\u308b\u3053\u3068\u3067\u3001\u751f\u4f53\u306b\u6709\u76ca\u306a\u52b9\u80fd\u3092\u53ca\u307c\u3059\u3082\u306e\u3067\u3042\u308b\u3068\u3082\u8a00\u3048\u308b\u3002
\uff11\uff09\u6d88\u5316\u7ba1\u5185\u306e\u6709\u5bb3\u83cc\uff08\u304a\u3088\u3073\u30d4\u30ed\u30ea\u83cc\u3092\u542b\u3080\u75c5\u539f\u83cc\uff09\u3092\u76f4\u63a5\u6291\u5236\u3059\u308b\u3002\u6a5f\u5e8f\u3068\u3057\u3066\u306fcolonization resistance\u3068\u7dcf\u79f0\u3055\u308c\u308b\u6804\u990a\u3084\u5bbf\u4e3b\u7c98\u819c\u3078\u306e\u5b9a\u7740\uff0f\u4ed8\u7740\u90e8\u4f4d\u3092\u6709\u5bb3\u83cc\u3068\u62ee\u6297\u3059\u308b\u3053\u3068\u3067\u596a\u3046\u3001\u3042\u308b\u3044\u306f\u6709\u6a5f\u9178\uff08\u4e73\u9178\u3001\u9162\u9178\u306a\u3069\uff09\u3084\u30d0\u30af\u30c6\u30ea\u30aa\u30b7\u30f3\u3092\u5206\u6ccc\u3059\u308b\u3053\u3068\u3067\u3001\u6709\u5bb3\u83cc\u3092\u6291\u5236\u3057\u6bba\u83cc\u3059\u308b\u3002
\uff12\uff09\u96e3\u6d88\u5316\u6027\u591a\u7cd6\u985e\u306a\u3069\u306e\u6d88\u5316\u304a\u3088\u3073\u4ee3\u8b1d\u3092\u4fc3\u9032\u3057\u3001\u5bbf\u4e3b\u306e\u5fc5\u9808\u6804\u990a\u7d20\u3067\u3042\u308b\u30d3\u30bf\u30df\u30f3\u985e\u3084\u3001\u8178\u7ba1\u4e0a\u76ae\u7d30\u80de\u306e\u6804\u990a\u3068\u306a\u308b\u77ed\u9396\u8102\u80aa\u9178\u3092\u8178\u5185\u306b\u4f9b\u7d66\u3059\u308b\u3002
\uff13\uff09\u6d88\u5316\u7ba1\u6a5f\u80fd\uff08\u5438\u53ce\u3001\u904b\u52d5\u306a\u3069\uff09\u306e\u767a\u9054\u304a\u3088\u3073\u518d\u751f\u3092\u4fc3\u9032\u3059\u308b\u3002
\uff14\uff09\u8178\u5185\u3078\u306e\u5206\u6ccc\u578bIgA\u5206\u6ccc\u4fc3\u9032\u3042\u308b\u3044\u306fNK\u7d30\u80de\u6d3b\u6027\u5316\u306b\u3088\u308a\u7c98\u819c\u514d\u75ab\u9632\u5fa1\u80fd\u3092\u5897\u5f37\u3059\u308b\u3002<\/p>
\u3000\u73fe\u5728\u3001Pb\u306f\u611f\u67d3\u75c7\u3001\u708e\u75c7\u3001\u514d\u75ab\u30a2\u30ec\u30eb\u30ae\u30fc\u3001\u4ee3\u8b1d\u306e\u591a\u304f\u306e\u75be\u60a3\u306b\u6709\u52b9\u3042\u308b\u3044\u306f\u6709\u671b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u308b\u3002\u8868\uff11<\/strong><\/span>\u306f2001\u5e74\u306b\u56fd\u9023\u98df\u7ce7\u8fb2\u696d\u6a5f\u95a2\uff08FAO\uff09\u30fb\u4e16\u754c\u4fdd\u5065\u6a5f\u69cb\uff08WHO\uff09\u5408\u540c\u5c02\u9580\u5bb6\u4f1a\u8b70\u304b\u3089\u63d0\u793a\u3055\u308c\u305fPb\u306e\u5fdc\u7528\u306e\u5177\u4f53\u4f8b\u306b\u3001\u6700\u8fd1\u6ce8\u76ee\u3055\u308c\u3066\u3044\u308bPb\u5bfe\u8c61\u75be\u60a3\u3092\u52a0\u3048\u305f\u3082\u306e\u306e\u4e00\u89a7\u3067\u3042\u308b\u3002Pb\u306e\u751f\u4f53\u3067\u306e\u4f5c\u7528\u306e\u4e00\u822c\u7684\u306a\u7279\u5fb4\u3092\u611f\u67d3\u75c7\u306b\u304a\u3051\u308b\u6297\u751f\u7269\u8cea\u306e\u4f5c\u7528\u3068\u6bd4\u8f03\u3057\u3066\u8ff0\u3079\u308b\u3068\u3001\u6297\u751f\u7269\u8cea\u304c\u75c5\u539f\u83cc\u3092\u77ed\u6642\u9593\u3067\u6bba\u83cc\u3042\u308b\u3044\u306f\u9759\u83cc\u5316\u3059\u308b\u306e\u306b\u5bfe\u3057\u3001Pb\u306f\u6d88\u5316\u7ba1\u7d30\u83cc\u53e2\u3068\u3044\u3046\u30a8\u30b3\u30b7\u30b9\u30c6\u30e0\u3092\u4ecb\u3057\u3066\u3044\u308f\u3070\u9593\u63a5\u7684\u306b\u6297\u83cc\u52b9\u679c\u3092\u767a\u63ee\u3059\u308b\u3002\u3053\u306e\u305f\u3081\u3001Pb\u306f\u6025\u6027\u611f\u67d3\u75c7\u306e\u6cbb\u7642\u306b\u306f\u9069\u3055\u306a\u3044\u304c\u3001\u9577\u6642\u9593\u5b89\u5168\u306b\u6295\u4e0e\u3067\u304d\u308b\u306e\u3067\u3001\u611f\u67d3\u75c7\u4e88\u9632\u3042\u308b\u3044\u306f\u6162\u6027\u7d30\u83cc\u611f\u67d3\u75c7\u3067\u751f\u3058\u308b\u4e8c\u6b21\u7684\u75c5\u5909\uff08\u4f8b\uff1b\u30d4\u30ed\u30ea\u611f\u67d3\u306b\u3068\u3082\u306a\u3046\u6d88\u5316\u6027\u6f70\u760d\uff09\u306e\u767a\u75c7\u4e88\u9632\u306b\u9069\u3057\u3066\u3044\u308b\u3002Pb\u306f\u4f5c\u7528\u306e\u767a\u73fe\u304c\u7de9\u5f90\u3067\u3042\u308a\u3001\u591a\u304f\u306e\u5834\u5408\u3001\u4e00\u5b9a\u306e\u52b9\u679c\u3092\u5f97\u308b\u306e\u306b\u6708\u5358\u4f4d\u306e\u7d99\u7d9a\u6295\u4e0e\u304c\u5fc5\u8981\u306a\u306e\u3082\u3001\u305d\u306e\u7279\u5fb4\u306e\u4e00\u3064\u3067\u3042\u308b\u3002<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
\n\t\t\t\t\n\t\t\t\u8868\uff11\t \u30d7\u30ed\u30d0\u30a4\u30aa\u30c6\u30a3\u30af\u30b9\u306e\u5fdc\u7528\u7bc4\u56f2<\/h6>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\n\t\t\t\t\t\t\t\t\n\t\t\t\t\n\t\t\t\u75be\u60a3<\/h6>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\t\uff11. \u6d88\u5316\u7ba1\u306b\u95a2\u9023\u3057\u305f\u75be\u60a3<\/p>
\u3000\uff11\uff09\u6b6f\u5468\u75c5\u00a0
\u3000\uff12\uff09\u7d30\u83cc, \u30a6\u30a4\u30eb\u30b9\u306b\u3088\u308b\u4e0b\u75e2
\u3000\uff13\uff09\u30d8\u30ea\u30b3\u30d0\u30af\u30bf\u30fc\u30d4\u30ed\u30ea\u83cc\u611f\u67d3\u3068\u305d\u306e\u5408\u4f75\u75c7
\u3000\uff14\uff09\u6a5f\u80fd\u6027\u30c7\u30a3\u30b9\u30da\u30d7\u30b7\u30a2
\u3000\uff15\uff09\u708e\u75c7\u6027\u8178\u75be\u60a3
\u3000\uff16\uff09\u904e\u654f\u6027\u5927\u8178
\u3000\uff17\uff09\u764c
\u3000\uff18\uff09\u4fbf\u79d8<\/p>
\uff12.\u3000\u7c98\u819c\u514d\u75ab<\/p>
\uff13.\u3000\u30a2\u30ec\u30eb\u30ae\u30fc<\/p>
\uff14.\u3000\u5fc3\u8840\u7ba1\u75be\u60a3<\/p>
\uff15.\u3000\u80a5\u6e80, \u7cd6\u5c3f\u75c5<\/p>
\uff16.\u3000\u8001\u5316<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
\n\t\t\t\n\t\t\t\t\t\t\t\t\n\t\t\t\t\n\t\t\t\u5bfe\u8c61\u3068\u306a\u308b\u75c5\u539f\u83cc\/\u75be\u75c5\u75c5\u614b<\/h6>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\t\u30b8\u30f3\u30b8\u30d0\u30ea\u30b9\u83cc
\u30b5\u30eb\u30e2\u30cd\u30e9\u83cc, \u30af\u30ed\u30b9\u30c8\u30ea\u30b8\u30a6\u30e0\u83cc, \u30ed\u30bf\u30a6\u30a4\u30eb\u30b9\u6162\u6027\u80c3\u708e, \u80c3\u5341\u4e8c\u6307\u8178\u6f70\u760d, \u80c3\u764c<\/p>
Crohn\u75c5, \u6f70\u760d\u6027\u5927\u8178\u708e<\/p>
\u80c3\u764c, \u5927\u8178\u764c, \u8180\u80f1\u764c<\/p>
\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8, NK\u7d30\u80de, slgA<\/p>
\u98df\u7269\u30a2\u30ec\u30eb\u30ae\u30fc, \u30a2\u30c8\u30d4\u30fc\u6027\u76ae\u819a\u708e, \u6c17\u7ba1\u652f\u5598\u606f<\/p>
\u8840\u4e2d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb<\/p>
\u4f53\u8102\u80aa, \u8010\u7cd6\u80fd<\/p>
\u52d5\u8108\u786c\u5316, Alzheimer<\/span>\u75c5\u00a0 \u00a0<\/span><\/span><\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
\n\t\t\t\t\n\t\t\t\t\t\u80c3\u3067\u50cd\u304fPb<\/strong><\/p>
\u8178\u306b\u306f\uff11\uff10\uff10\u5146\u500b\u3082\u306e\u81a8\u5927\u306a\u6570\u306e\u5e38\u5728\u7d30\u83cc\u304c\u5b9a\u4f4f\u3057\u3066\u3044\u308b\u3002\u4e00\u65b9\u3001\u30d2\u30c8\u306e\u80c3\u306f\u5f37\u3044\u80c3\u9178\u306e\u305f\u3081\u3001\u5f93\u6765\u306e\u57f9\u990a\u6cd5\u306b\u3088\u308b\u691c\u7d22\u3067\u306f\u5e38\u5728\u83cc\u306f\u307b\u3068\u3093\u3069\u5b58\u5728\u305b\u305a\u3001\u80c3\u6db2\uff11ml\u3042\u305f\u308a\u305b\u3044\u305c\u3044\uff11\uff10^{\uff13<\/sup>\u500b\u691c\u51fa\u3055\u308c\u308b\u7a0b\u5ea6\u3067\u3001\u305d\u306e\u591a\u304f\u306f\u30ec\u30f3\u30b5\u7403\u83cc\u3001\u4e73\u9178\u687f\u83cc\u3067\u3042\u308b\u3002\u3057\u304b\u3057\u3001\u840e\u7e2e\u6027\u80c3\u708e\u3084\u80c3\u9178\u5206\u6ccc\u6291\u5236\u5264\u306e\u9577\u671f\u9023\u7528\u306b\u3088\u308a\u80c3\u9178\u5206\u6ccc\u304c\u4f4e\u4e0b\u3057\u305f\u80c3\u3067\u306f\u3001\u5e38\u5728\u83cc\u306e\u6570\u306f\u5897\u52a0\u3057\uff11\uff10^{\uff18<\/sup>\uff0fml\u306b\u3082\u9054\u3059\u308b\u3002\u3059\u306a\u308f\u3061\u3001\u80c3\u306f\u6f5c\u5728\u7684\u306b\u306f\u4e73\u9178\u687f\u83cc\u306a\u3069\u306b\u3088\u308b\u5e38\u5728\u7d30\u83cc\u53e2\u304c\u5f62\u6210\u3055\u308c\u3046\u308b\u90e8\u4f4d\u3067\u3042\u308b\u304c\u3001\u5f37\u3044\u80c3\u9178\u306e\u5b58\u5728\u304c\u3053\u308c\u3092\u963b\u3093\u3067\u3044\u308b\u3002<\/p>}}
\u3000\u3053\u308c\u306b\u5bfe\u3057\u3066\u3001\u7b46\u8005\u3089\u306f\u4ee5\u524d\u304a\u3053\u306a\u3063\u305f\u30d4\u30ed\u30ea\u83cc\u611f\u67d3\u5b9f\u9a13\u3067\u3001\u901a\u5e38\u74b0\u5883\u3067\u80b2\u3063\u305f\u3044\u308f\u3086\u308bSPF\u30de\u30a6\u30b9\u306f\u3001\u30d4\u30ed\u30ea\u83cc\u3092\u7d4c\u53e3\u63a5\u7a2e\u3057\u3066\u3082\u80c3\u306b\u611f\u67d3\u304c\u6210\u7acb\u3059\u308b\u3053\u3068\u304c\u56f0\u96e3\u3067\u3042\u308b\u3053\u3068\u3092\u89b3\u5bdf\u3057\u305f^{\uff11\uff09<\/sup>\u3002\u305d\u306e\u539f\u56e0\u3092\u691c\u8a0e\u3057\u305f\u3068\u3053\u308d\u3001\u3053\u308c\u3089\u306e\u30de\u30a6\u30b9\u3067\u306f\u80c3\u306b\u4e73\u9178\u687f\u83cc\u3092\u4e3b\u3068\u3059\u308b\u5e38\u5728\u7d30\u83cc\u53e2\u304c\u6210\u7acb\u3057\u3066\u3044\u308b\u305f\u3081\u3001\u30d4\u30ed\u30ea\u83cc\u306f\u80c3\u306b\u4fb5\u5165\u3057\u3066\u3082\u3053\u308c\u3089\u4e73\u9178\u687f\u83cc\u306b\u6392\u9664\u3055\u308c\u3066\u3057\u307e\u3046\u3053\u3068\u304c\u308f\u304b\u3063\u305f\u3002\u30de\u30a6\u30b9\u306e\u80c3\u306f\u9178\u6027\u5ea6\u304cpH\uff14\u7a0b\u5ea6\u3068\u5f31\u3044\u305f\u3081\u4e73\u9178\u83cc\u304c\u5b9a\u4f4f\u3067\u304d\u308b\u3068\u8003\u3048\u3089\u308c\u305f\u3002\u4e00\u65b9\u3001\u30d2\u30c8\u306e\u80c3\u306f\u9178\u6027\u5ea6\u304cpH\uff11\u301c\uff12\u3068\u5f37\u3044\u305f\u3081\u3001\u901a\u5e38\u306e\u4e73\u9178\u83cc\u306f\u80c3\u306b\u68f2\u606f\u3067\u304d\u306a\u3044\u3002\u5f93\u3063\u3066\u30d2\u30c8\u306e\u80c3\u3067\u3082Pb\u3092\u7528\u3044\u3066\u30d4\u30ed\u30ea\u83cc\u3092\u6392\u9664\u3059\u308b\u305f\u3081\u306b\u306f\u3001\u305d\u306ePb\u306f\u80c3\u9178\u3078\u306e\u8010\u6027\u304c\u3042\u308a\u3001\u304b\u3064\u80c3\u7c98\u819c\u306b\u4ed8\u7740\u80fd\u3092\u6709\u3059\u308b\u3053\u3068\u3067\u3001\u80c3\u306b\u3042\u308b\u7a0b\u5ea6\u306e\u6642\u9593\u3001\u751f\u304d\u3066\u3068\u3069\u307e\u308b\u3053\u3068\u304c\u53ef\u80fd\u3067\u306a\u3051\u308c\u3070\u306a\u3089\u306a\u3044\u3002\u3053\u308c\u3089\u306e\u691c\u8a0e\u3092\u3082\u3068\u306b\u3001\u7b46\u8005\u3089\u306f\u30d2\u30c8\u306e\u80c3\u3067\u30d4\u30ed\u30ea\u83cc\u306b\u5bfe\u3057\u3066\u6291\u5236\u52b9\u679c\u3092\u767a\u63ee\u3059\u308bPb\u3068\u3057\u3066\u3001\u7d042000\u7a2e\u306e\u4e73\u9178\u687f\u83cc\u682a\u304b\u3089LG21\uff08Lactobacillus gasseri<\/em> OLL2716\uff09\u682a\uff08\u56f3\uff11<\/strong><\/span>\uff09\u3092\u9078\u3073\u51fa\u3057\u305f\u3002<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t}
\n\t\t\t\t\n\t\t\t\u56f31<\/h6>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\tLG21\u682a\u306f\u4ed6\u306e\u4e73\u9178\u687f\u83cc\u682a\u306b\u6bd4\u3079\u9ad8\u3044\u80c3\u9178\u8010\u6027\u3068\u80c3\u7c98\u819c\u4ed8\u7740\u80fd\u3092\u6301\u3064\u306e\u304c\u7279\u9577\u3067\u3042\u308b\u3002LG21\u3092\u6210\u4eba\u306e\u30d4\u30ed\u30ea\u83cc\u611f\u67d3\u8005\u306b\u6442\u53d6\u3057\u3066\u3082\u3089\u3046\u4e88\u5099\u7684\u81e8\u5e8a\u8a66\u9a13\u3067\u306f\u3001\uff11\u65e510^{9<\/sup>\u500b\u3092\u6bce\u65e5\uff16\u9031\u9593\u6442\u53d6\u3059\u308b\u3053\u3068\u3067\u3001\u80c3\u5185\u30d4\u30ed\u30ea\u83cc\u6570\u304c\u7d04\uff11\uff10\u5206\u306e\uff11\u306b\u6e1b\u5c11\u3057\u3001\u80c3\u7c98\u819c\u708e\u75c7\u304c\u6709\u610f\u306b\u8efd\u6e1b\u3057\u305f^{\uff12\uff09<\/sup>\u3002<\/p>}}
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\u3000Pb\u306b\u3088\u308b\u30d4\u30ed\u30ea\u83cc\u6291\u5236\u6a5f\u5e8f\u3068\u3057\u3066\u3053\u308c\u307e\u3067\u8ff0\u3079\u305f\u6a5f\u5e8f\u306b\u52a0\u3048\u3066\u3001Pb\u304c\u4e73\u9178\u83cc\u3067\u3042\u308b\u5834\u5408\u306f\u305d\u306e\u5206\u6ccc\u3059\u308b\u4e73\u9178\u3084\u9162\u9178\u304c\u30d4\u30ed\u30ea\u83cc\u306b\u5bfe\u3057\u3066\u76f4\u63a5\u306e\u6bba\u83cc\u52b9\u679c\u3092\u767a\u63ee\u3059\u308b\u3002\u307e\u305f\u3001\u6297\u83cc\u7269\u8cea\u3067\u3042\u308b\u30d0\u30af\u30c6\u30ea\u30aa\u30b7\u30f3\u3092\u5206\u6ccc\u3059\u308b\u3053\u3068\u3067\u30d4\u30ed\u30ea\u83cc\u3092\u6291\u5236\u3059\u308bPb\u682a\u3082\u3042\u308b\u3002<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
\n\t\t\t\t\n\t\t\t\u56f32<\/h6>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\n\t\t\t\t\n\t\t\t\u56f33<\/h6>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\t\u9664\u83cc\u7642\u6cd5\u9069\u5fdc\u62e1\u5927\u6642\u4ee3\u306b\u304a\u3051\u308bPb<\/strong>\u306e\u5b58\u5728\u610f\u7fa9<\/strong><\/p>
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\u00a0<\/span><\/p>
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\n\t\t\t\t\n\t\t\t\u8868\uff12\t \u30d4\u30ed\u30ea\u83cc\u611f\u67d3\u75c7\u306b\u5bfe\u3059\u308bPb\u5358\u72ec\u6295\u4e0e\u306e\u52b9\u679c<\/h6>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\n\t\t\t\t\n\t\t\t\n\n\n\n\n\n\n\n\n\n\n\u00a0<\/caption>\n\u8a66\u9a13\u65b9\u6cd5<\/span><\/strong><\/span><\/td>\n \u88ab\u9a13\u8005\uff08\u75c7\u4f8b\u6570\uff09<\/strong><\/span><\/td>\n \u7528\u3044\u305fPb\u306e\u83cc\u682a\u3068\u91cf<\/span><\/strong><\/span><\/td>\n \u7d50\u679c<\/span><\/strong><\/span><\/td>\n \u53c2\u7167\u6587\u732e<\/span><\/strong><\/span><\/td>\n<\/tr>\n<\/thead>\n
R, P<\/span><\/td>\n \u7121\u75c7\u5019\u6210\u4eba(14)<\/span><\/td>\n L. casei Shirota<\/em>, 1.95\u00d710^{10<\/sup>,\u00a0for 3 weeks<\/span><\/td>\n} \u52b9\u679c\u306a\u3057<\/span><\/td>\n Cats et al<\/em>.<\/span>\nBr J Nutr<\/em> 2000<\/span><\/td>\n<\/tr>\n
P<\/span><\/td>\n \u7121\u75c7\u5019\u6210\u4eba(31)<\/span><\/td>\n L. gasseri<\/em> OLL 2716,\u00a02.2\u00d710^{9<\/sup>\/day for 8 weeks<\/span><\/td>\n} \u5c3f\u7d20\u547c\u6c17\u30c6\u30b9\u30c8\u6539\u5584<\/span>\n\u8840\u4e2dPG\u2160\/\u2161\u6bd4 \u4e0a\u6607<\/span><\/td>\n Sakamoto et al<\/em>.<\/span>\nJ Antimicrob Chemother<\/em> 2001<\/span><\/td>\n<\/tr>\n
O<\/span><\/td>\n \u6709\u75c7\u5019\u5e7c\u5150(12)\u00a0\u00a0\u00a0\u00a0<\/span><\/td>\n L. gasseri<\/em> OLL 2716,\u00a0for 8 weeks<\/span><\/td>\n \u5c3f\u7d20\u547c\u6c17\u30c6\u30b9\u30c8\u4e0d\u5909<\/span>\n\u4fbf\u4e2d\u30d4\u30ed\u30ea\u83cc\u6297\u539f\u91cf\u4f4e\u4e0b<\/span>\n\u8840\u4e2dPG\u2160\/\u2161\u6bd4 \u4e0a\u6607<\/span><\/td>\n Shimizu et al<\/em>.<\/span>\nJ Antimicrob Chemother<\/em> 2002<\/span><\/td>\n<\/tr>\n
R, DB, P<\/span><\/td>\n \u7121\u75c7\u5019\u5e7c\u5150(236)\u00a0<\/span><\/td>\n L. johnsonii <\/em>La1<\/span>\nL.paracasei<\/em> ST11<\/span>\n\u00a01.8\u00d710^{9<\/sup>\/day for 4 weeks<\/span><\/td>\n} \u5c3f\u7d20\u547c\u6c17\u30c6\u30b9\u30c8\u6539\u5584<\/span><\/td>\n Cruchet et al<\/em>.<\/span>\nNutrition<\/em> 2003<\/span><\/td>\n<\/tr>\n
R, DB, P<\/span><\/td>\n \u7121\u75c7\u5019\u6210\u4eba(50)<\/span><\/td>\n L. johnsonii <\/em>La1 acidified milk for 3 and 16 weeks<\/span><\/td>\n \u80c3\u708e\u6539\u5584<\/span>\n\u80c3\u7c98\u819c\u30d4\u30ed\u30ea\u83cc\u5bc6\u5ea6\u4f4e\u4e0b<\/span>\n\u80c3\u7c98\u819c\u5c64\u5897\u5927<\/span><\/td>\n Pantoflickova et al<\/em>.<\/span>\nAliment Pharmacol\u00a0<\/em>Ther<\/em> 2003<\/span><\/td>\n<\/tr>\n
R<\/span><\/td>\n \u7121\u75c7\u5019\u5e7c\u5150(254)\u00a0<\/span><\/td>\n S. boulardii<\/em> (500mg\/day)\u00a0+ inulin (10g\/day)<\/span>\nL. acidophilus<\/em> LB\u00a0(heat inactivated),10^{10<\/sup>\/day\u00a0for 8 weeks<\/span><\/td>\n} \u9664\u83cc\u7387 12% (Sb) <\/span>\n\u9664\u83cc\u7387 6.5\uff05 (L b)<\/span><\/td>\n Gotteland et al<\/em>.<\/span>\nActa Paediatr<\/em> 2005<\/span><\/td>\n<\/tr>\n
DB, \u4e8c\u91cd\u76f2\u691c; R, \u30e9\u30f3\u30c0\u30e0\u5316; P, \u30d7\u30e9\u30bb\u30dc\u5bfe\u7167; O, \u30aa\u30fc\u30d7\u30f3<\/span><\/td>\n<\/tr>\n
\u201c Systemic review : are probiotics useful in controlling gastric colonization by H.pylori<\/em>\u201d\nGotteland et al. ; Aliment Pharmacol Ther<\/em> 23 : 1077-1086, 2006. \u3092\u4e00\u90e8\u6539\u5909<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\t\u30d4\u30ed\u30ea\u83cc\u6297\u751f\u7269\u8cea\u9664\u83cc\u7642\u6cd5\u3078\u306ePb\u306e\u4f75\u7528<\/strong><\/p>
\u3000\u6297\u751f\u7269\u8cea\u306bPPI\uff08\u30d7\u30ed\u30c8\u30f3\u30dd\u30f3\u30d7\u963b\u5bb3\u5264\uff09\u3092\u52a0\u3048\u305f\u30d4\u30ed\u30ea\u83cc\u9664\u83cc\u7642\u6cd5\u306f\u3001\u30d4\u30ed\u30ea\u83cc\u611f\u67d3\u75c7\u6cbb\u7642\u306e\u7b2c\u4e00\u9078\u629e\u3068\u3055\u308c\u3066\u3044\u308b\u3002\u6211\u304c\u56fd\u3067\u3082\u6297\u751f\u7269\u8cea\u3068\u3057\u3066\u30af\u30e9\u30ea\u30b9\u30ed\u30de\u30a4\u30b7\u30f3\u3068\u30a2\u30e2\u30ad\u30b7\u30b7\u30ea\u30f3\u3092\uff11\u9031\u9593\u9023\u65e5\u6295\u4e0e\u3059\u308b\u4e00\u6b21\u9664\u83cc\u7642\u6cd5\u304c\u5e83\u304f\u666e\u53ca\u3057\u3066\u3044\u308b\u3002\u9664\u83cc\u7642\u6cd5\u306b\u4f34\u3046\u526f\u4f5c\u7528\u3068\u3057\u3066\u4e3b\u306a\u3082\u306e\u306f\u3001\u4e0b\u75e2\u3001\u8179\u90e8\u81a8\u6e80\u306a\u3069\u306e\u6d88\u5316\u5668\u75c7\u72b6\u3067\u3042\u308b\u304c\u3001\u3053\u308c\u3089\u306f\u670d\u85ac\u30b3\u30f3\u30d7\u30e9\u30a4\u30a2\u30f3\u30b9\u3092\u4e0b\u3052\u9664\u83cc\u7387\u306e\u4f4e\u4e0b\u306b\u3064\u306a\u304c\u308b\u3002\u6297\u751f\u7269\u8cea\u9664\u83cc\u7642\u6cd5\u306bPb\u3092\u4f75\u7528\u3059\u308b\u3053\u3068\u3067\u3001\u526f\u4f5c\u7528\u51fa\u73fe\u3092\u4e88\u9632\u3057\u3066\u9664\u83cc\u7387\u5411\u4e0a\u3092\u76ee\u6307\u3059\u8a66\u307f\u304c\u3053\u308c\u307e\u3067\u6570\u591a\u304f\u5b9f\u65bd\u3055\u308c\u3066\u304d\u305f\u3002\u8868\uff13<\/strong><\/span>\u306b\u305d\u306e\u4e3b\u306a\u5831\u544a^{\uff14\uff09<\/sup>\u3092\u307e\u3068\u3081\u305f\u3002<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t}
\n\t\t\t\t\n\t\t\t\u8868\uff13\t \u30d4\u30ed\u30ea\u83cc\u6297\u751f\u7269\u8cea\u9664\u83cc\u7642\u6cd5\u3078\u306ePb\u306e\u4f75\u7528\u52b9\u679c<\/h6>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\n\t\t\t\t\n\t\t\t\n\n\n\n\n\n\n\n\n\n\n\n\n\u00a0<\/caption>\n\u8a66\u9a13\u65b9\u6cd5<\/span><\/strong><\/td>\n \u30d4\u30ed\u30ea\u83cc(+)\u88ab\u9a13\u8005\n\uff08\u75c7\u4f8b\u6570\uff09<\/span><\/strong><\/td>\n \u9664\u83cc\u7642\u6cd5\u85ac\u5264<\/span><\/strong><\/td>\n \u4f75\u7528\u3057\u305fPb\u306e\u83cc\u682a\u3068\u91cf<\/span><\/strong><\/td>\n \u7d50\u679c<\/span><\/strong><\/td>\n \u53c2\u7167\u6587\u732e<\/span><\/strong><\/td>\n<\/tr>\n<\/thead>\n
R, O<\/span><\/td>\n \u6709\u75c7\u5019\u6210\u4eba(120)<\/span><\/td>\n Rabeprazole, clarithromycin,\u00a0amoxicillin<\/span><\/td>\n L. acidophilus<\/em> LB,\u00a0for 10 days<\/span><\/td>\n ER\u4e0a\u6607<\/span>\nAE\u4e0d\u5909<\/span><\/td>\n Canducci et al<\/em>.<\/span>\nAliment Pharmacol Ther <\/em>2000<\/span><\/td>\n<\/tr>\n
R, O<\/span><\/td>\n \u7121\u75c7\u5019\u6210\u4eba(120)<\/span><\/td>\n Pantoprazole, clarithromycin,\u00a0imidazole<\/span><\/td>\n L. rhamnosus <\/em>GG,\u00a01.2\u00d710^{10<\/sup>\/day<\/span>\u00a0for 10 days<\/span><\/td>\n} ER\u4e0d\u5909<\/span>\nAE\u6e1b\u5c11<\/span><\/td>\n Armuzzi et al<\/em>.<\/span>\nDigestion <\/em>2001<\/span><\/td>\n<\/tr>\n
R, O<\/span><\/td>\n \u6709\u75c7\u5019\u6210\u4eba(160)\u00a0\u00a0\u00a0\u00a0<\/span><\/td>\n Lansoprazole, clarithromycin,\u00a0amoxicillin<\/span><\/td>\n L. acidophilus<\/em> LA5,\u00a0+B. lactis<\/em> Bb12, 10^{10<\/sup>\/day for 4 weeks \u00a0<\/span><\/td>\n} ER\u4e0a\u6607<\/span><\/td>\n Sheu et al<\/em>.<\/span>\nAliment Pharmacol Ther<\/em> 2002<\/span><\/td>\n<\/tr>\n
R, P, DB<\/span><\/td>\n \u7121\u75c7\u5019\u6210\u4eba(85)<\/span><\/td>\n Rabeprazole, clarithromycin,\u00a0tinidazole<\/span><\/td>\n L. rhamnosus <\/em>GG,\u00a0S. boulardii\u00a0Lactobacillus LA5,\u00a0+B. lactis Bb12,\u00a0for 2 weeks<\/em><\/span><\/td>\n ER\u4e0d\u5909<\/span>\nAE\u6e1b\u5c11<\/span><\/td>\n Cremonini et al<\/em>.<\/span>\nAm J Gastroenterol<\/em> 2002<\/span><\/td>\n<\/tr>\n
R<\/span><\/td>\n \u6709\u75c7\u5019\n\u304b\u3064\u9664\u83cc\u5931\u6557\u8005\u6210\u4eba(70)<\/span><\/td>\n Esomeprazole or pantoplazole,\nranitidine bismuth citrate,\u00a0 \u00a0amoxicillin\u00a0and tinidazole\u00a0\u00a0<\/span><\/td>\n L. casei <\/em>DG,\u00a01.6\u00d710^{10<\/sup>\/day\u00a0for 10 days\u00a0 \u00a0<\/span><\/td>\n} ER\u4e0d\u5909<\/span>\nAE\u6e1b\u5c11<\/span><\/td>\n Tursi et al<\/em>.<\/span>\nMed Sci Monit <\/em>2004<\/span><\/td>\n<\/tr>\n
R, P, DB<\/span><\/td>\n \u6709\u75c7\u5019\u5c0f\u5150(86)<\/span><\/td>\n Omeprazole, clarithromycin,\u00a0amoxicillin<\/span><\/td>\n L. casei <\/em>DN,\u00a010^{10<\/sup>\/day for 2 weeks<\/span><\/td>\n} ER\u4e0a\u6607<\/span>\nAE\u6e1b\u5c11<\/span><\/td>\n Sykora et al<\/em>.<\/span>\nJ Clin Gastroenterol<\/em> 2005<\/span><\/td>\n<\/tr>\n
R, P, DB<\/span><\/td>\n \u6709\u75c7\u5019\u5c0f\u5150(83)<\/span><\/td>\n Omeprazole, clarithromycin, amoxicillin\u00a0<\/span><\/td>\n L.GG<\/em>\u00a02\u00d710^{9<\/sup> for 1 weeks<\/span><\/td>\n} ER\u4e0a\u6607<\/span>\nAE\u6e1b\u5c11<\/span><\/td>\n Szajewska et al<\/em>.<\/span>\nJ Pediatr Gastroenterol<\/em>\u00a0<\/span>\nNutr<\/em> 2009 \u00a0<\/span><\/td>\n<\/tr>\n
R<\/span><\/td>\n \u7121\u75c7\u5019\u6210\u4eba(229)\u00a0\u00a0\u00a0\u00a0<\/span><\/td>\n Rabeplazole, clarithromycin,\u00a0amoxicillin<\/span><\/td>\n L. gasseri<\/em> OLL2716,\u00a010^{9<\/sup>\/day for 4 weeks<\/span><\/td>\n} ER\u4e0a\u6607<\/span>\nAE\u6e1b\u5c11<\/span><\/td>\n Deguchi et al<\/em>.<\/span>\nJ Gastroenterol Hepatorol<\/em> 2011<\/span><\/td>\n<\/tr>\n
DB, \u4e8c\u91cd\u76f2\u691c; R, \u30e9\u30f3\u30c0\u30e0\u5316; P, \u30d7\u30e9\u30bb\u30dc\u5bfe\u7167; O, \u30aa\u30fc\u30d7\u30f3; ER, \u9664\u83cc\u7387; AE, \u526f\u4f5c\u7528<\/span><\/td>\n<\/tr>\n
\u201c Systemic review : are probiotics useful in controlling gastric colonization by H.pylori<\/em>\u201d\nGotteland et al. ; Aliment Pharmacol Ther<\/em> 23 : 1077-1086, 2006. \u3092\u4e00\u90e8\u6539\u5909<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\t\uff12\uff10\uff10\uff14\u5e74\u307e\u3067\u306b\u5831\u544a\u3055\u308c\u305fPb\u4f75\u7528\u81e8\u5e8a\u8a66\u9a13\u306b\u3064\u3044\u3066\u306eGotteland\u3089\u306e\u30ec\u30d3\u30e5\u30fc^{\uff14\uff09<\/sup>\u3067\u306f\u3001\u300cPb\u306e\u4f75\u7528\u306f\u9664\u83cc\u7642\u6cd5\u306b\u4f34\u3046\u526f\u4f5c\u7528\u306e\u8efd\u6e1b\u306b\u306f\u6709\u52b9\u3067\u3042\u308b\u304c\u3001\u9664\u83cc\u7387\u306e\u5411\u4e0a\u306b\u306f\u5fc5\u305a\u3057\u3082\u7d50\u3073\u3064\u304b\u306a\u3044\u300d\u3068\u8ff0\u3079\u3066\u3044\u308b\u3002\u3057\u304b\u3057\uff12\uff10\uff10\uff16\u5e74\u307e\u3067\u306e\u81e8\u5e8a\u8a66\u9a13\u5831\u544a\u3092\u7528\u3044\u3066\u5b9f\u65bd\u3055\u308c\u305fTong\u3089\u306e\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9^{\uff15\uff09<\/sup>\u3067\u306f\u3001\u300cPb\u4f75\u7528\u306b\u3088\u308a\u9664\u83cc\u7387\u304c\u6709\u610f\u306b\u5411\u4e0a\u3057\u305f\u300d\u3068\u7d50\u8ad6\u3065\u3051\u3066\u3044\u308b\u3002\u3059\u306a\u308f\u3061\u5f7c\u3089\u306fPb\u4f75\u7528\u306b\u3064\u3044\u3066\u306e\u30e9\u30f3\u30c0\u30e0\u5316\u81e8\u5e8a\u8a66\u9a13\u3001\u8a08\uff11\uff14\u5831\uff08n=1671\uff09\u3092\u89e3\u6790\u3057\u305f\u3068\u3053\u308d\u3001\u9664\u83cc\u7642\u6cd5\u306e\u307f\u3067\u306e\u9664\u83cc\u7387\uff17\uff14\uff0e\uff18\uff05\uff08ITT\u89e3\u6790\uff09\u304c\u3001Pb\u4f75\u7528\u306b\u3088\u308a\uff18\uff13\uff0e\uff16\uff05\u306b\u5411\u4e0a\u3057\u305f\u3002\u307e\u305f\u526f\u4f5c\u7528\u767a\u73fe\u983b\u5ea6\u3082\uff13\uff18\uff0e\uff15\uff05\u304b\u3089\uff12\uff14\uff0e\uff17\uff05\u306b\u4f4e\u4e0b\u3057\u305f\u3002\u3053\u308c\u3089\u306e\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\u306f\u3059\u3079\u3066\u6210\u4eba\u3067\u306e\u6210\u7e3e\u306b\u57fa\u3065\u3044\u305f\u3082\u306e\u3067\u3042\u308b\u30022013\u5e74\u306b\u5831\u544a\u3055\u308c\u305f\u5c0f\u5150\u30d4\u30ed\u30ea\u83cc\u611f\u67d3\u8005\u306b\u304a\u3051\u308b\u9664\u83cc\u7642\u6cd5\u3078\u306ePb\u4f75\u7528\u52b9\u679c\u306b\u3064\u3044\u3066\u306e\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9^{\uff16\uff09<\/sup>\u3067\u3082\u3001Pb\u4f75\u7528\u306b\u3088\u308b\u9664\u83cc\u6210\u529f\u7387\u306e\u30aa\u30c3\u30ba\u6bd4\u306fITT\u304a\u3088\u3073PP\u5206\u6790\u306b\u304a\u3044\u3066\u3001\u305d\u308c\u305e\u308c1.96\u30012.25\u3068\u6709\u610f\u306a\u4e0a\u6607\u304c\u8a8d\u3081\u3089\u308c\u305f\u3002\u4e00\u65b9\u3001\u526f\u4f5c\u7528\u51fa\u73fe\u983b\u5ea6\u306f0.32\u3068\u6e1b\u5c11\u3057\u3066\u3044\u305f\u3002\u3053\u306e\u3088\u3046\u306b\u8fd1\u5e74\u306b\u306a\u3063\u3066Pb\u4f75\u7528\u304c\u9664\u83cc\u7387\u5411\u4e0a\u306b\u3082\u5bc4\u4e0e\u3059\u308b\u3088\u3046\u306b\u306a\u3063\u305f\u80cc\u666f\u3068\u3057\u3066\u3001\u6297\u751f\u7269\u8cea\u3068\u304f\u306b\u30af\u30e9\u30ea\u30b9\u30ed\u30de\u30a4\u30b7\u30f3\u8010\u6027\u30d4\u30ed\u30ea\u83cc\u5897\u52a0\u306b\u3088\u308b\u3001\u8fd1\u5e74\u306e\u9664\u83cc\u7387\u4f4e\u4e0b\u304c\u8003\u3048\u3089\u308c\u308b\u3002\u56fd\u5185\u3067\u306f\u4ee5\u524d\u306f\uff19\uff10\uff05\u4ee5\u4e0a\u3067\u3042\u3063\u305f\u4e00\u6b21\u7642\u6cd5\u306b\u3088\u308b\u9664\u83cc\u6210\u529f\u7387\u304c\u3001\u6700\u8fd1\u3067\u306f\uff17\uff10\uff05\u524d\u5f8c\u306b\u4f4e\u4e0b\u3057\u3066\u3044\u308b\u3002Ushiyama\u3089^{\uff17\uff09<\/sup>\u306f\u3001\u4e73\u9178\u83ccLG21\u306f\u30af\u30e9\u30ea\u30b9\u30ed\u30de\u30a4\u30b7\u30f3\u8010\u6027\u30d4\u30ed\u30ea\u83cc\u306b\u5bfe\u3057\u3066\u3082\u611f\u53d7\u6027\u30d4\u30ed\u30ea\u83cc\u306b\u5bfe\u3059\u308b\u306e\u3068\u540c\u69d8\u306e\u9ad8\u3044\u6291\u5236\u52b9\u679c\u3092\u767a\u63ee\u3059\u308b\u3053\u3068\u3092\u3001\u611f\u67d3\u52d5\u7269\u30e2\u30c7\u30eb\u3092\u7528\u3044\u3066\u660e\u3089\u304b\u306b\u3057\u305f\u3002\u3055\u3089\u306b\u6700\u8fd1Deguchi\u3089^{8<\/sup>^{\uff09<\/sup>\u306f\u3001Pb\u3068\u3057\u3066LG21\u3092\u7528\u3044\u3066\u3001Pb\u4f75\u7528\u306e\u9664\u83cc\u4e0a\u4e57\u305b\u52b9\u679c\u3092\u691c\u8a0e\u3059\u308b\u30e9\u30f3\u30c0\u30e0\u5316\u5bfe\u7167\u6bd4\u8f03\u8a66\u9a13\u3092\u5b9f\u65bd\u3057\u305f\uff08n=229\uff09\u3002\u30e9\u30d9\u30d7\u30e9\u30be\u30fc\u30eb\u3001\u30af\u30e9\u30ea\u30b9\u30ed\u30de\u30a4\u30b7\u30f3\u3001\u30a2\u30e2\u30ad\u30b7\u30b7\u30ea\u30f3\u306e\uff11\u9031\u9593\u6295\u4e0e\u7fa4\u3068\u3001\u3053\u308c\u3089\uff13\u5264\u306bLG21\uff08\uff11\uff10^{\uff19<\/sup>x\uff12\uff0f\u65e5\uff09\u3092\uff14\u9031\u9593\uff08\uff13\u5264\u6295\u4e0e\uff13\u9031\u9593\u524d\u304b\u3089\u6295\u4e0e\u7d42\u4e86\u307e\u3067\uff09\u4f75\u7528\u3059\u308b\u7fa4\u3068\u306b\u5206\u3051\u3066\u6bd4\u8f03\u691c\u8a0e\u3057\u305f\u3002\u305d\u306e\u7d50\u679c\u3001\uff13\u5264\u306e\u307f\u306e\u9664\u83cc\u7387\u306fITT\u89e3\u6790\u3067\uff16\uff19\uff0e\uff13\uff05\u3067\u3042\u3063\u305f\u306e\u306b\u5bfe\u3057\u3001LG21\u4f75\u7528\u7fa4\u3067\u306f\uff18\uff12\uff0e\uff16\uff05\u3068\u6709\u610f\u306b\u5411\u4e0a\u3057\u305f\uff08p<\/em>=0.018\uff09\u3002\u3055\u3089\u306b\u6cbb\u7642\u524d\u306e\u907a\u4f1d\u5b50\u89e3\u6790\u3067\u3001\u30af\u30e9\u30ea\u30b9\u30ed\u30de\u30a4\u30b7\u30f3\u8010\u6027\u30d4\u30ed\u30ea\u83cc\u4fdd\u83cc\u8005\u3067\u3042\u308b\u3053\u3068\u304c\u308f\u304b\u3063\u3066\u3044\u305f\u88ab\u9a13\u8005\uff15\uff11\u540d\u306b\u3064\u3044\u3066\u5c64\u5225\u89e3\u6790\u3092\u884c\u3063\u305f\u3068\u3053\u308d\u3001\u9664\u83cc\u7387\u306f\uff13\u5264\u306e\u307f\u3067\u306f\uff12\uff18\uff0e\uff10\uff05\u306b\u5bfe\u3057\u3001Pb\u4f75\u7528\u3067\u306f\uff13\uff18\uff0e\uff15\uff05\u3068\u4e0a\u6607\u306e\u50be\u5411\u3092\u793a\u3057\u305f\uff08p<\/em>=0.46\uff09\u3002\u3053\u308c\u3089\u306e\u7d50\u679c\u306f\u3001\u8fd1\u5e74\u306e\u9664\u83cc\u7387\u4f4e\u4e0b\u304c\u30af\u30e9\u30ea\u30b9\u30ed\u30de\u30a4\u30b7\u30f3\u8010\u6027\u30d4\u30ed\u30ea\u83cc\u306e\u5897\u52a0\u306b\u3088\u308b\u3082\u306e\u3067\u3042\u308b\u3053\u3068\u3001\u3055\u3089\u306bPb\u4f75\u7528\u306b\u3088\u308b\u9664\u83cc\u7387\u306e\u5411\u4e0a\u306f\u3001\u526f\u4f5c\u7528\u3092\u8efd\u6e1b\u3059\u308b\u3053\u3068\u3067\u306e\u670d\u85ac\u30b3\u30f3\u30d7\u30e9\u30a4\u30f3\u30b9\u6539\u5584\u306b\u52a0\u3048\u3001Pb\u306e\u8010\u6027\u30d4\u30ed\u30ea\u83cc\u306b\u5bfe\u3059\u308b\u76f4\u63a5\u306e\u9664\u83cc\u52b9\u679c\u304c\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u793a\u5506\u3057\u305f\u3002<\/p>}}}}}}}
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\u00a0<\/p>
\u6587\u732e<\/p>
\uff11\uff09Kabir AM, Aiba Y, Takagi A, et al: Prevention of Heliocbacter pylori <\/em>infection by lactobacilli in a gnotobiotic murine model. Gut 41: 49-55, 1997<\/p>
\uff12\uff09Sakamoto I, Igarashi M, Kimura K et al: Suppressive effect of Lactobacillus gasseri<\/em> OLL2716 (LG21) on Helicobacter pylori<\/em> infection in humans. J Antimicrob Chemother 47: 709-710, 2001.<\/p>
\uff13\uff09Tamura A, Kumai H, Nakamichi N, et al: Suppression of Helicobacter pylori<\/em>-induced interleukin-8 production in vitro<\/em> and within the gasric mucosa by a live Lactobacillus<\/em> strain. J Gastroenterol Hepatol 21: 1399-1406, 2006.<\/p>
\uff14\uff09Gotteland M, Brunser O, Cruchet S: Systemic review: are probiotics useful in controlling gastric colonization by Helicobacter pylori<\/em>? Aliment Pharmacol Ther 23: 1077-1086, 2006<\/p>
\uff15\uff09Tong JL, Ran ZH, Shen J et al: Meta-analysis: the effect of supplementation with probiotics on eradication rates and adverse events during Helicobacter pylori<\/em> eradication therapy. Aliment Pharmacol Ther 25: 155-168, 2007<\/p>
\uff16\uff09Li S, Huang X-l, Sui J-z, et al: Meta analysis of randomized controlled trials on the efficacy of probiotics in Helicobacter pylori<\/em> eradication therapy in children. Eur J Pediatr (Published online 10 December 2013; DOI 10.1007\/s00431-013-2220-3)<\/p>
7) Ushiyama A, Tanaka K, Aiba Y et al: Lactobacillus gasseri<\/em> OLL2716 as a probiotic in clarithromycin-resistant Helicobacter pylori<\/em> infection. J Gastroenterol Hepatol 18: 986-991, 2003.<\/p>
8) Deguchi R, Nakaminami H, Rimbara H et al: Effect of pretreatment with Lactobacillus gasseri OLL2716 on first-line Helicobacter pylori eradication therapy. J Gastroenterol Hepatol 27: 888-892, 2012.<\/p>
9) Malfertheiner P, Megraud F, O\u2019Morain CA, et al: Management of Helicobacter pylori<\/em> infection-the Maastricht IV\/Florence consensus report. Gut 61:646-664, 2012.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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