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1.<\/b> Kabir, A.M.A., Aiba, Y., Takagi, A., Kamiya, S., Miwa, T. and Koga, Y. 1997. Prevention of Helicobacter pylori infection by Lactobacilli in a gnotobiotic model. Gut 41: 49-55. <\/p>\n

2.<\/b> Sudo, N., Sawamura, S., Tanaka, K., Aiba, Y., Kubo, C. and Koga, Y. 1997. The requirement of intestinal bacterial flora for the development of IgE production system fully susceptible to oral tolerance induction. J. Immunol. 159: 1739-1745. <\/p>\n

3.<\/b> Aiba. Y., Suzuki, N., Kabir, A.M.A., Takagi, A. and Koga, Y. 1998. Lactic acid-mediated suppression of Helicobacter pylori by the oral administration of Lactobacillus salivarius as a probiotic in agnotobiotic murine model. Am. J. Gastroenterol. 93: 2097-2102. <\/p>\n

4.<\/b> Kohda, K., Tanaka, K., Aiba, Y., Yasuda, M., Miwa, T. and Koga, Y. 1999. The role of apoptosis induced by Helicobacter pylori infection in the development of duodenal ulcer. Gut 44: 456-462. <\/p>\n

5.<\/b> Wada, T., Aiba, Y., Shimizu, K., Takagi, A., Miwa, T. and Koga, Y. 1999. The therapeutic effect of bovine Lactoferrin in the host infected with Helicobacter pylori. Scand. J. Gastroenterol. 34: 238-243. <\/p>\n

6.<\/b> Takagi, A., Watanabe, S., Igarashi, M., Koike, J., Hasumi, K., Deguchi, R., Koga, Y., and Miwa, T. 2000. The effect of Helicobacter pylori on cell proliferation and apoptosis in gastric epithelial cell lines. Aliment. Pharmacol. Ther.14( Suppl. 1) 188-192. <\/p>\n

7.<\/b> Igarashi, M., Kitada, Y., Yoshiyama, H., Takagi, A., Miwa, T., and Koga, Y. 2001. Ammonia as an accelerator of tumor necrosis factoralpha-induced apoptosis of gastric epithelial cells in Helicobacte pylori\u3000infection. Infect. Immun. 69\uff1a816-821. <\/p>\n

8.<\/b> Sakamoto, I., Igarashi, M., Kimura, K., Takagi, A., Miwa, T., and Koga, Y. 2001. Suppressive effect of Lactobacillus gasseri OLL 2716 (LG21) on Helicobacter pylori infection in humans.J. Antimicrobia. Chemother. 47\uff1a709-710. <\/p>\n

9.<\/b> Sudo, N., Yu. X-N., Aiba. Y., Oyama. N., Sonoda. J., Koga. Y., and Kubo, C. 2002 . An oral introduction of intestinal bacteria prevents the development of a long -term Th2-skewed immunological memory induced by neonatal antibiotic treatment in mice. Clin. Exp. Allergy.32: 1112-1116. <\/p>\n

10.<\/b> Ushiyama A., Tanaka K., Aiba Y., Shiba T., Takagi A., Mine. T., Koga Y. 2003 . Lactobacillus gasseri OLL2716 as a probiotic in clarithromycin-resistant Helicobacter pylori infection J. Gastroenterol.Hepatol. 18 : 986-991. <\/p>\n

11.<\/b> Ishikawa H.,Aiba Y.,Nakanishi M.,Oh-hashi Y.,Koga Y. 2003.Suppression of periodontal pathogenic bacteria in the saliva of humans by the administration of Lactobacillus salivarius TI2711 J. Jpn. Soc. Periodontol. 45 : 105-112. <\/p>\n

12.<\/b> Sudo N., Chida Y., Aiba Y., Sonoda J., Oyama N., Yu X-N., Kubo C., and Koga Y. 2004. Postnatal microbial colonization programs thehypothalamic-pituitary-adrenal system for stress response in mice. J. Physiol. 558. 1 : 263-275. <\/p>\n

13.<\/b> Sudo N., Aiba Y., Oyama N., Yu X-N., Matsunaga M., Koga Y., Kubo C. 2004. Dietary Nucleic Acid and Intestinal Microbiota SynergisticallyPromote a Shift in the Th1\/Th2 Balance toward Th1h-Skewed\u3000Immunity. Int Arch Allergy Immunol. ; 135 : 132-135. <\/p>\n

14.<\/b> Matsuoka T., Nakanishi M., Aiba Y., and Koga Y. 2004. Mechanism of Porphyromonas gingivalis killing by Lactobacillus salivarius TI2711. J. Jpn. Soc. Periodontol. 46: 118-126. <\/p>\n

15.<\/b> Matsuoka T., Sugano N., Ito K., and Koga Y. 2005. Effect of oral Lactobacillus salivarius TI2711administration on periodontal status and periodontopathic bacteria in subgingival plaque. J. Jpn. Soc. Periodontol. 47: 194-202. <\/p>\n

16.<\/b> Suzuki N., Aiba Y., Takeda H., Fukumori Y., and Koga Y. 2006. Superiority of 1-kestose, the smallest fructo-oligosaccharide, to a synthetic mixture of fructo-oligosaccharides in the selective stimulating activity on bifidobacteria. Bioscience Microflora. 25: 109-116. <\/p>\n

17.<\/b> Tamura A., Kumai H., Nakamichi N., Sugiyama T., Deguchi R., Takagi A., and Koga Y. 2006. Suppression of Helicobacter pylori-induced interleukin-8 production in vitro and within the gastric mucosa by a live lactobacillus strain. J. Gastroenterol Hepatol. 21: 1399-1406. <\/p>\n

18.<\/b> Boonyaritichaikij S., Kuwabara K., Nagano J., Kobayashi K., and Koga Y. 2009. Long-term administration of probiotics to asymptomatic pre-school children for either the eradication or the prevention of Helicobacter pylori infection. Helicobacter 14: 202-207. <\/p>\n

19.<\/b> Mikami K., Takahashi H., Kimura M., Isozaki M., Izuchi K., Shibata R., Sudo N., Matsumoto H., and Koga Y. 2009. Influence of maternal bifidobacteria on the establishment of bifidobacteria colonizing the gut in infants. Pediatr Res 65: 669-674. <\/p>\n

20.<\/b> Shibata R., Kimura M., Takahashi H., Mikami K., Aiba Y., Takeda H., and Koga Y. 2009. Clinical effects of kestose, a prebiotic oligosaccharide, on the treatment of atopic dermatitis in infants. Clin Exp Allergy 39: 1397-1403. <\/p>\n

21.<\/b> Takahashi H., Mikami K., Nishino R., Matsuoka T., Kimura M., and Koga Y. 2010. Comparative analysis of the properties of bifidobacterial isolates from fecal samples of mother-infant psirs. J. Pediatric Gastoroenterology and Nutrition. 51: 653-660. <\/p>\n

22.<\/b> Takahashi H., Nakano Y., Matsuoka T., Kumaki N., Asami Y., and Koga Y. 2011. Role of indigenous Lactobacilli in gastrin-mediated acid production in the mouse stomach. Applied and Environmental Microbiology. 77: 6964-6971. <\/p>\n

23.<\/b> Akama F., Nishino R., Makino S., Kobayashi K., Kamikaseda K., Nagano J., and Koga Y. 2011. The effect of probiotics on gastric mucosal permeability in humans administered with aspirin. Scandinavian Journal of Gastroenterology. 46: 831-836. <\/p>\n

24.<\/b> Nishino R., Mikami K., Takahashi H., Tomonaga S., Furuse M., Hiramoto T., Aiba Y., Koga Y., and Sudo N. 2013. Commensal microbiota modulate murine behaviors in a strictly contamination-free environment confirmed by culture-based methods. Neurogastroenterology & Motility 25:521-528. <\/p>\n

25.<\/b> Shirai T., Suzuki Y., Kamikado K., Koga Y., and Aoki R. 2013. Kestose, a prebiotic fructooligosaccharide, enhances intercellular tight junction recovery via a rho-associated kinase-dependent mechanism in intestinal caco-2 cells. International Journal of Probiotics and Prebiotics. 8: 53-60. <\/p>\n

26.<\/b> Igarashi M., Nagano J., Tsuda A., Suzuki T., Koike J., Uchida T., Matsushima M., Mine T., and Koga Y. 2014. Correlation between the Serum Pepsinogen I Level and the Symptom Degree in Proton Pump Inhibitor-Users Administered with a Probiotic. Pharmaceuticals 7: 754-764. <\/p>\n

27.<\/b> Sadahiro S., Suzuki T., Tanaka A., Okada K., Kamata H., Ozaki T., and Koga Y. 2014. Comparison between oral antibiotics and probiotics as bowel preparation for elective colon cancer surgery to prevent infection: Prospective randomized trial. Surgery 155: 493-503. <\/p>\n

28.<\/b> Matsuoka T., Koga Y. 2014. The differences in the sensitivity of the Porhyromonas Gingivalis fimAgenotypes to a probiotic Lactobacillus strain, LS1, in the oral cavity of patients: double blind clinical trial. International Journal of Probiotics and Prebiotics 9: 4: 135-140. <\/p>\n

29.<\/b> Tsuda A., Suda W., Morita H., Takanashi K., Takagi A., Koga Y., and Hattori M. 2015. Influence of Proton-Pump Inhibitore on the Luminal Microbiota in the Gastrointestinal Tract. Clinical and Translational Gastroenterology 6: e89: doi: 10.1038ctg.2015020. <\/p>\n

30.<\/b> S. Sirilun, Takahashi H., S. Boonyaritichaikij, C. Chaiyasut, P. Lertruangpanya, Koga Y., and Mikami K. 2015. Impact of maternal bifidobacteria and the mode of delivery on Bifidobacterium microbiota in infants. Benefical Microbes 2015 online DOI 10.3920\/BM2014.0124 <\/p>\n

31.<\/b> A. Takagi, H. Yanagi, H. Ozawa, N. Uemura, S. Nakajima, K. Inoue, T. Kawai, T. Ohtsu and Y. Koga. Effect of Lactobacillus gasseri OLL2716 on Helicobacter pylori-associated dyspepsia: A multicenter randomized double-blind controlled trial. Gastroenterology Research and Practice. 2016. http:\/\/dx.doi.org\/10.1155\/2016\/7490452 <\/p>\n

32.<\/b> Koga Y, Tokunaga S, Nagano J, Sato F, Konish K, Tochio T, Murakami Y, Masumoto N, Tezuka J, Sudo N, Kubo C and Shibata R. 2016;80:844-851. Age-associated effect of kestose on Faecalibacterium prausnitzii and symptoms in the atopic dermatitis infants. Pediatric Research doi:10.1038\/pr.2016.167 <\/p>\n

33.<\/b> Nakae H, Tsuda A, Matsuoka T, Mine T, and Koga Y. 2016;3:e000109. Gastric microbiota in the funcional dyspepsia patients treated with probiotic yogurt. BMJ Open Gastro. doi:10.1136\/bmjgast-2016-000109 <\/p>\n

34.<\/b> Igarashi M, Nakae H, Matsuoka T, Takahashi S, Hisada T, Tomita J, and Koga Y. 2017;3:e000144. Alteration in the gastric microbiota and its restoration by probiotics in patients with functional dyspepsia. BMJ Open Gastro. doi:10.1136\/bmjgast-2017-000144 <\/p>\n

36.<\/b> Ohtsu T, Takagi A, Uemura N, Inoue K, Sekino H, Kawashima A, Uchida M, and Koga Y. 2017. The ameliorating effect of Lactobacillus gasseri OLL2716 on functional dyspepsia in Helicobacter pylori-uninfected individuals: A randomized controlled study. Digestion 2017;96:92-102. <\/p>\n

37.<\/b> Aoki R, Kamikado K, Suda W, Takii H, Mikami Y, Suganuma N, Hattori M, and Koga Y. 2017. A proliferative probiotic Bifidobacterium strain in the gut ameliorates progression of metabolic disorders via microbiota modulation and acetate elevation. Scientific Reports 7:43522. <\/p>\n

38.<\/b> Tochio T, Kadota Y, Tanaka T, and Koga Y. 2018, Review; 1-kestose, the smallest fructooligosaccharide component, which efficiently stimulates Faecalibacterium prausnitzii as well as bifidobacteria in humans. Foods 2018, 7, 140; doi:10.3390\/foods7090140<\/p>\n

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